Developmental Accumulation of Gene Body and Transposon Non-CpG Methylation in the Zebrafish Brain
Our latest is out in Frontiers in Cell and Developmental Biology. Here we demonstrate that zebrafish, just like mammals, accumulate non-canonical DNA methylation (mCH) during brain development. Moreover, we identify accumulation of mCH at transposons from the Tc1-mariner superfamily. Overall, this work demonstrates the evolutionary conservation of developmental mCH dynamics and highlights the potential of zebrafish as a model to study mCH regulation and function during normal and perturbed development (i.e Rett syndrome).