Evolution of DNA methylome diversity in eukaryotes

Our lab has participated in the special issue of the Journal of Molecular Biology: “Reading DNA modifications”. We contributed with a review: “Evolution of DNA methylome diversity in eukaryotes”. In this piece, we summarise a decade worth of insights obtained from whole genome bisulfite sequencing studies across eukaryotes. We speculate on the origins and functions of diverse DNA methylation patterns observed in different organisms and propose how such patterns might have evolved. This work expands our knowledge on the function and evolutionary origins of DNA methylation in plants, animals and fungi. The bonus was that our artwork (designed by Scot Nicholls) was selected for the cover of this special issue.

JMB_cover

Evolutionary conservation of DNA methylation loss during chordate development. Hourglass represents the developmental morphological divergence across species, where the mid-developmental phylotypic stage shows similar morphologies across distant taxa whereas early and late development are more prone to lineage specific forms.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s